Remeron Side Effects: What You Need to Know Before Taking This Antidepressant
When you start taking Remeron, a prescription antidepressant also known as mirtazapine, used to treat major depressive disorder and sometimes anxiety or insomnia. Also known as mirtazapine, it works differently than SSRIs like Lexapro or Zoloft — it targets brain chemicals that affect sleep, appetite, and mood all at once. That’s why it’s often chosen for people who struggle with sleep or have lost their appetite because of depression. But that same mechanism is also why side effects like drowsiness and weight gain are so common.
One of the most frequent complaints? Feeling sleepy — sometimes so much that people take it at night on purpose. About 60% of users report drowsiness in the first few weeks, and it usually fades after a month. But for some, it sticks around. Weight gain is another big one. Studies show people on Remeron gain an average of 5 to 10 pounds in the first few months, mostly from increased hunger and slower metabolism. It’s not a diet drug — it’s the opposite. If you’re already worried about your weight, this is something to discuss with your doctor before starting. Less common, but more serious, are side effects like dizziness, dry mouth, constipation, and in rare cases, changes in blood cell counts. That’s why your doctor will likely check your blood early on, especially if you’re on it long-term.
Remeron doesn’t usually cause the nausea or sexual side effects you see with other antidepressants, which is why many people switch to it. But that doesn’t mean it’s harmless. If you suddenly feel unusually tired, have a fever, or notice unexplained bruising or sore throat, stop taking it and call your doctor — those could be signs of a rare blood disorder. And don’t mix it with alcohol or other sedatives. The combo can slow your breathing to dangerous levels. If you’ve tried other meds that made you feel wired or emotionally flat, Remeron might feel like a relief. But if you’re sensitive to changes in appetite or energy, it might feel like a trade-off you didn’t sign up for.
Below, you’ll find real-world insights from people who’ve taken Remeron, what worked for them, what didn’t, and how to spot the warning signs early. Whether you’re considering it, just started, or have been on it for months, this collection gives you the unfiltered details you won’t get from a drug label.
Mirtazapine and Weight Gain: What You Need to Know About This Common Side Effect
Mirtazapine often causes weight gain due to its effect on appetite and metabolism. About 25% of users gain 7% or more of their body weight. Learn why it happens, how much is typical, and how to manage it without stopping the medication.